CENTURY II Multivessel disease | Terumo Interventional Systems

Overview

This study reveals, that throughout the 5-year follow-up period, sirolimus-eluting bioresorbable polymer Ultimaster™ stent (BP-SES), displays similarly good long-term safety and efficacy profile as the everolimus-eluting permanent polymer Xience stent (PP-EES), in the treatment of MVD patients.

Study Design

Study Outline

Patient background

	BP-SES n=225	PP-EES n=231	p Value
Age, years	65.8±10.4	66.9±11.3	.31
Male gender	77.8	84.0	.09
Body mass index, kg/m²	27.3±4.2	26.8±4.2	.27
Slent Ischemla	16.4	16.5	.99
Stable angina	48.9	42.9	.20
Unstable angina	12	9.1	.31
STEMI	4.9	7.4	.27
NSTEMI	17.8	24.2	.09
Dlabetes melltus, 　　IDDM 　　NIDDM	37.3 21.4 78.6	33.3 18.2 81.8	.37 .61 .61
Dyslipidemia	71.0	71.1	.99
Hypertonsion	74.1	71.2	.49
Smoker, current	19.6	24.3	.23
Smoker, previous	48.9	37.6	.02
Renal insufficiency,	4.0	3.0	.57
Fanmily history of CAD	31.9	32.9	.83
History of PCI	44.4	40.3	.37
History of CABG	7.1	6.5	.79
History of MIl	31.1	32.5	.76
Charlson comorbidity index	1.5±1.8	1.3±1.6	.39
Vassels diseased (LM included)	2.3±0.5	2.3±0.5	.16
Number of vessels diseased (LM included) 　　2 　　3 　　4	75.1 23.6 1.3	69.3 28.6 2.2	.15
Vessels treated	1.4±0.5	1.4±0.6	.87
Number of vassals treated 　　1 　　2 　　3	59.6 39.1 1.3	59.3 38.1 2.6	.76
SYNTAX score	12.7±8.7	12.3±7.6	.91

	BP-SES N patients 225 N lesions364	PP-EES N patients 231 N lesions 374	p Value
Lesions detectod	3.1±1.5	3.1±1.3	.57
Leslons treated	1.6±0.8	1.6±0.8	.93
Lesion lacation 　　RCA 　　LAD 　　CFX 　　LM 　　Graft	30.5 37.9 28.3 2.5 0.8	32.4 34.2 30.8 2.4 0.3	.80
Ostial	7.5	9.9	.24
Calcification 　　None/mild 　　Moderate 　　 Severe	76.2 16.1 7.8	81.8 11.6 6.6	.32
Thrombus present	3.7	3.9	.93
Blfurcatlon	14.8	10.7	.09
CTO	2.2	0.3	.02
ACC/AHA classification 　　A 　　B1 　　B2 　　C	3.5 12.1 48.9 35.6	2.8 16.9 49.7 30.7	.14
Access site 　　Radial 　　Femoral 　　Brachial	69.8 28.9 1.3	68.4 30.3 1.3	.77
Pre-dilatation	76.1	76.2	.97
Post dilatation	51	49.5	.68
Stents Implanted per patient	1.9±1.0	2.0±1.1	.30
Total Implanted stent length per patient, mm	36.5±20.1	37.5±22.4	.93
Delivery success per stent	98.3	99.4	.15
Procedure success	97.3	97.8	.73

Note. Values represent either mean + SD or % of either per patient or perlesion calculation.
Abbreviations: ACC/AHA, American College of Cardiology/American Heart Association; CFX, left circumflex coronary artery; CTO, chronic totalocclusion; LAD, left anterior descending coronary artery; LM, left main coronary artery; RCA, right coronary artery.